Impact of chemotherapy on humoral and cellular immune responses to COVID-19 vaccination in patients with solid tumors.

Front Immunol · 2025 · PMC12507793 · PMID 41080595

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showed a trendno p-value reported

Conversely, in ChT-treated patients the antibody response showed a trend towards shorter persistence and a statistically significantly lower responsiveness to the booster dose for both anti-spike (p < 0.01) and anti-RBD IgG (p < 0.05).

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did not reach statistical significanceno p-value reported

We observed that spike-specific B cells were induced at post-vaccination at T1 and further increased with the booster dose (T1b), with particularly high frequencies in some patients, although these differences did not reach statistical significance ( Figure 5A ).

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