The Potential Protective Effects of Intermittent Fasting Against Radiation-Induced Brain Damage in a Rat Model: Suggested Involvement of IRS-1/PI3 K/AKT and BDNF/TrkB Signaling Pathways.

Mol Neurobiol · 2025 · PMC12511218 · PMID 40591178

Europe PMC DOI

hedged sentences

0.0001

closest p · 0.0× alpha

0.0770

boldest claim

The sentences

highly significantp < 0.0001actually significant

Analysis of 8-OHdG, a biomarker of oxidative DNA damage, revealed highly significant main effects of diet ( F (2, 30) = 185.6, p < 0.0001) and radiation ( F (1, 30) = 2892, p < 0.0001), as well as a robust interaction between these factors ( F (2, 30) = 177.8, p < 0.0001).

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approached significancep = 0.0571so close (0.05 < p ≤ 0.1)

The comparison between ADF and TRF in week 3 approached significance (mean difference = − 13.1, p = 0.0571), suggesting a trend toward greater weight reduction with ADF (Fig. 2 a).

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did not reach statistical significancep = 0.0770so close (0.05 < p ≤ 0.1)

By week 3, ADF rats exhibited a significantly lower %BWC compared to the NF group (mean difference = 25.5, p < 0.0001), while the difference between TRF and NF did not reach statistical significance (mean difference = 12.5, p = 0.0770).

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