A pan-cancer single-cell analysis reveals the effect of PD-1 blockades on tumor angiogenesis by inhibiting the endothelial CXCL12-CXCR4 axis.

Cancer Immunol Immunother · 2025 · PMC12511515 · PMID 41065842

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0.2700

closest p · 5.4× alpha

0.2700

boldest claim

The sentences

did not reach statistical significancep = 0.27not close (p > 0.1)

Moreover, in an anti-PD-1 treatment cohort from TCGA, the CXCL12-high group showed a tendency toward poorer prognosis, but this association did not reach statistical significance ( p = 0.27).

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showed a trendno p-value reported

We compared the CXCL12 expression of ECs and fibroblasts in two conditions, and the result shows that CXCL12 was significantly reduced in ECs ( p = 0.00004) in treated tumors, while the expression only showed a trend to increase in fibroblasts (Fig. 3 F).

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