Efficacy, Safety, and Biomarkers of Neoadjuvant Dalpiciclib (CDK4/6 inhibitor) plus Aromatase Inhibitors in Operable HER2-Negative Luminal B Breast Cancer: A Prospective, Single-Center, Single-Arm, Phase II Trial (DANCER).

Additionally, baseline carcinoembryonic antigen (CEA) levels were significantly associated with CCCA at T1 (Figure 3F ), and histological grade showed a trend toward association ( p = 0.075; Figure 3E ).

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As neoadjuvant therapy progressed, the levels of most proteins exhibited a decreasing trend (Figures 6F and S5 ).

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Circulating Tumor DNA While ctDNA was detectable in some MRs at T0 + , T2, S, and PO, it was consistently undetectable in all GRs at the same time points, although the difference did not reach statistical significance (Figure 4B ).

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