Pre-ICU statin therapy reduces 28-day mortality in sepsis-associated brain dysfunction: a propensity-matched analysis of potential neuroprotective mechanisms.

Front Pharmacol · 2025 · PMC12517583 · PMID 41089840

Europe PMC DOI

hedged sentences

0.0740

closest p · 1.5× alpha

0.0740

boldest claim

The sentences

showed a trendp = 0.074so close (0.05 < p ≤ 0.1)

ICU mortality showed a trend towards reduction in the statin group (3.7% vs. 6.7%, OR: 0.543, 95% CI: 0.278–1.062, p = 0.074), while hospital length of stay was comparable between groups (8.21 vs. 8.71 days, OR: 0.997, 95% CI: 0.985–1.008, p = 0.544) ( Table 2 ).

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did not reach statistical significanceno p-value reported

Secondary outcomes showed trends toward reduced ICU mortality and shorter ICU stays in statin users, though these associations did not reach statistical significance after adjustment.

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