Cold storage of mouse hearts prior to cardiomyocyte isolation preserves electromechanical function, microstructure, and gene expression for 24 h.

Basic Res Cardiol · 2025 · PMC12518438 · PMID 40728729

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did not reach statistical significanceno p-value reported

2 C) during the initial depolarization phase appeared reduced in the CSP group (148.44 ± 13.97 mV/ms) in comparison to CTRL and CS (198.1 ± 15.7 and 225.9 ± 15.6 mV/ms respectively), although this trend did not reach statistical significance.

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highly significantno p-value reported

However, highly significant differences in TATS features appear between the CSP48h and CSP72h group compared to CTRL, indicating a change in cellular quality, in case of storage periods longer than 24 h.

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showed a trendno p-value reported

The resting sarcomere length was higher and sarcomere shortening showed a trend toward lower values, whereas contraction kinetics were not different in CSP.

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