Combining immune-related adverse events and inflammatory profiles enhances prognostic accuracy in metastatic melanoma under PD-1-based therapy.

Front Immunol · 2025 · PMC12521244 · PMID 41103410

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.1320

boldest claim

The sentences

showed a trendp=0.057so close (0.05 < p ≤ 0.1)

Vitiligo (n=10) significantly correlated with improved OS (HR=0.230; 95% CI: 0.057-0.936; p=0.040) and showed a trend for better PFS (HR=0.417; 95% CI: 0.169-1.026; p=0.057).

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a favorable trendp=0.065so close (0.05 < p ≤ 0.1)

Impact of type of organ-specific irAEs on survival Cutaneous irAEs were associated with a favorable trend toward improved PFS and OS (p=0.065), especially in the higher-line group.

also in 1,335 other papers

did not reach statistical significancep=0.132not close (p > 0.1)

For patients with ≥2 irAEs, the trend was similar but did not reach statistical significance (PFS: HR=0.552, p=0.132; OS: HR=0.486, p=0.107).

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