Cytokine and Chemokine-Associated Signatures Underlying Dermal Invasion and Skin Metastasis in Melanoma.

Int J Mol Sci · 2025 · PMC12524697 · PMID 41096602

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a negative trendno p-value reported

Ratios of invasive to non-invasive populations further suggested trends for CCR5 , TNFRSF11B , and IL6ST , and a negative trend for IL4R , indicating potential roles in modulating melanoma invasion in the dermal microenvironment.

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did not reach statistical significanceno p-value reported

While some findings did not reach statistical significance, concordant trends between in vitro and patient-derived data suggest their relevance and warrant further investigation in larger cohorts.

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