The efficacy and safety of pharmacological treatment for major depressive episode with mixed features specifier: a systematic review and meta-analysis.

Psychol Med · 2025 · PMC12527531 · PMID 41054794

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a suggestive trendp = 0.06so close (0.05 < p ≤ 0.1)

However, antipsychotic treatment was associated with a significantly increased overall risk of common AEs (RR = 2.33 [95% CI: 1.63,3.34], p < 0.001; NNH = 17 [95% CI: 11,25]; Supplementary Figure 8 ); this increased risk was particularly evident for arousal-related AEs (RR = 2.77, p = 0.005) and other common AEs (RR = 2.03, p = 0.003), with a suggestive trend for EPS-related AEs (RR = 2.56, p = 0.06).

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showed a trendp = 0.06so close (0.05 < p ≤ 0.1)

Subgroup analyses showed a trend toward efficacy for the RCT (lumateperone) on response rate (RR = 1.32, p = 0.06), while post-hoc analyses demonstrated significant benefit (RR = 1.35, p < 0.001; Supplementary Figure 11 ).

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