Genetic insights into lipid traits and atherosclerosis risk: a Mendelian randomization and polygenic risk score analysis.

Int J Surg · 2025 · PMC12527805 · PMID 40793967

Europe PMC DOI

hedged sentences

0.0974

closest p · 1.9× alpha

0.0974

boldest claim

The sentences

did not reach statistical significanceP = 9.74e−02so close (0.05 < p ≤ 0.1)

HDL showed a slight positive association in the discovery cohort (OR = 1.022, 95% CI = 1.008–1.035, P = 1.50e−03), but this association did not reach statistical significance in the replication cohort (OR = 1.254, 95% CI = 0.960–1.638, P = 9.74e−02) (Figure 4 A-C).

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a significant trendno p-value reported

In the replication cohort, genetically predicted increases in LDL levels also showed a significant trend toward increased AS risk (Fig. 2 D).

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