Genome-wide association meta-analysis and rare copy number variant analysis of treatment-resistant depression.

Mol Psychiatry · 2025 · PMC12532596 · PMID 40571737

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nominally significantno p-value reported

All three loci were nominally significant in a recent GWAS meta-analysis on MDD [ 71 , 75 ], and a TRD study based on predicted ECT probability [ 16 ], strengthening their relevance (Supplementary Table 16 ).

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did not reach statistical significanceno p-value reported

We also observed a positive genetic correlation of TRD risk with neuroticism ( r g = 0.65, SE = 0.12), whereas genetic correlation with other personality traits, including agreeableness, conscientiousness, openness, and extraversion, did not reach statistical significance.

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