Barely Significant
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A multimodal uncertainty-aware AI system optimizes ovarian cancer risk assessment workflow.

NPJ Digit Med · 2025 · PMC12533055 · PMID 41102390

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hedged sentences
0.0160
closest p · 0.3× alpha
0.0160
boldest claim

The sentences

nominally significantP = 0.016actually significant
After correcting for multiple comparisons (Holm-Bonferroni), stepwise improvements in balanced metrics (F1 score and MCC) remained statistically robust across both internal and external cohorts, whereas the observed increases in AUC and sensitivity-focused F2 score—although nominally significant in certain cases (e.g., external cohort AUC nominal P = 0.016)—did not consistently survive multiple testing correction.

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Although increases in AUC (to 0.955, P = 0.606) and F2 score (to 0.866, P = 0.083) at this stage were observed, these did not reach statistical significance.

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did not achieve significanceno p-value reported
Although positive trends were also noted for AUC (to 0.926, P = 0.940) and F2 score (to 0.757, P = 0.146), these changes did not achieve significance after adjusting for multiple comparisons.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.