Prognostic impact of hand-foot skin reaction in regorafenib-treated adult-type diffuse gliomas: A multicenter Turkish Oncology Group study.

Sci Rep · 2025 · PMC12533162 · PMID 41102268

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.2400

boldest claim

The sentences

showed a trendp = 0.060so close (0.05 < p ≤ 0.1)

5.45 months, p = 0.225), while patients who required dose reductions due to adverse events showed a trend toward longer OS compared with those without dose reduction (5.45 vs. 2.92 months, p = 0.060), although not statistically significant.

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did not reach statistical significancep = 0.240not close (p > 0.1)

Patients with IDH-wildtype glioblastoma had poorer median OS and PFS compared with those with IDH-mutant gliomas; however, these differences did not reach statistical significance (median OS: 3.84 vs. 5.78 months, p = 0.240; median PFS: 2.39 vs. 3.25 months, p = 0.249) (Fig. 2 ).

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