Electromagnetic Stimulation to Reduce Disability After Ischemic Stroke: The EMAGINE Randomized Clinical Trial.

Although there was no statistically significant difference between the intervention and sham control groups in change in global disability from baseline to 90 days after stroke, freedom from disability and ordinal level of disability outcomes at day 90 were nominally significant after adjustment for left-hemisphere stroke laterality, less baseline arm and hand weakness on the SAFE scale, and less total neurologic deficit on the NIHSS.

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Key Points Question Can electromagnetic network targeting field (ENTF) stimulation combined with physical and occupational therapy improve functional recovery in patients with moderate to severe disability after ischemic stroke? Findings In this randomized clinical trial of 100 patients, the change in disability level from baseline to day 90 after a stroke was numerically greater among patients in the active ENTF stimulation group than in the sham ENTF group, a difference that did not reach statistical significance.

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