An Integrative Analysis of O6-Methylguanine-DNA Methyltransferase (MGMT) Methylation and the Single-Nucleotide Polymorphism (SNP) rs1625649 Reveals Distinct Survival Patterns in Glioblastoma: A Retrospective Study.

Cureus · 2025 · PMC12535659 · PMID 41116956

Europe PMC DOI

hedged sentences

0.1280

closest p · 2.6× alpha

0.1280

boldest claim

The sentences

did not reach statistical significancep = 0.128not close (p > 0.1)

Female patients showed a higher proportion of MGMT methylation (48.6%) than males (32.8%), though the association did not reach statistical significance (p = 0.128).

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showed a trendno p-value reported

The CA genotype also showed a trend toward lower hazard compared to CC, but this was not statistically significant (HR = 0.77, 95% CI: 0.39-1.52, p = 0.450).

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