Progression of visual cognition and neuropsychiatric symptoms in Huntington's disease: a 1-year follow-up study across preclinical and clinical phases.

Front Psychol · 2025 · PMC12535969 · PMID 41122292

Europe PMC DOI

hedged sentences

0.0810

closest p · 1.6× alpha

0.0810

boldest claim

The sentences

showed a trendp = 0.081so close (0.05 < p ≤ 0.1)

Irritability showed a trend toward worsening in manifest carriers (β = −0.39, p = 0.081), with pre-manifest individuals exhibiting a modest but significant increase at follow-up (group*visit β = 0.39, p = 0.047).

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did not reach statistical significanceno p-value reported

Notably, the RP group—despite being motorically asymptomatic—presented elevated irritability and the highest levels of suicidal ideation at follow-up, although this difference did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.