Cul3 Postnatal Homozygous Deletion in Forebrain Results in Behavioral Differences

of day, F (7.957, 453.568) = 13.392, p < 0.0001; Main effect of day × genotype, F (15.915, 453.568) = 1.239, p > 0.05; Main effect of day × cre, F (7.957, 453.568) = 1.078, p > 0.05; Main effect of day × genotype × cre, F (15.915, 453.568) = 0.672, p > 0.05), where average distance traveled showed a trend toward increase in HOM Cre+ compared with WT Cre+ and WT Cre− controls (Figure S5D : Two‐way independent ANOVA: Main effect of genotype, F (2, 57) = 3.538, p < 0.05; Main effect of cre, F (1, 57) = 1.204, p > 0.05; Main effect of genotype × cre, F (2, 57) = 0.736, p > 0.05; Bonferroni: WT Cre− vs.

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In the first cohort, there was only a trend toward significance, while in our second cohort, this phenotype was robust and statistically significant.

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3.3 Increased Locomotor Activity In our initial cohort, HOM Cre+ mice demonstrated a strong trend toward increased locomotor activity in an open field compared to their littermate controls (Figure S2D : Welch's ANOVA: Main effect of genotype, W (2, 15.83) = 3.456, p = 0.0568).

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