Spatial analysis of tumor immune microenvironment of TNBC with different neoadjuvant chemotherapy outcomes using multiplex Immunofluorescence.

Breast Cancer Res · 2025 · PMC12539054 · PMID 41121362

Europe PMC DOI

hedged sentences

0.0570

closest p · 1.1× alpha

0.0710

boldest claim

The sentences

did not reach statistical significancep = 0.057so close (0.05 < p ≤ 0.1)

While the CD8 + IC/CD4 + FOXP3 + IC ratio was higher in the pCR group, this difference did not reach statistical significance (20.7 ± 18.6 vs. 1.1 ± 1.0, p = 0.057).

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showed a trendp = 0.071so close (0.05 < p ≤ 0.1)

In patients with low TIL levels, the stromal CD8 + IC/CD4 + FOXP3 + IC ratio showed a trend toward being higher in the pCR group (5.9 ± 0.8 vs. 3.2 ± 1.9, p = 0.071).

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