CDK4/6 and BET inhibitors synergistically suppress pancreatic tumor growth and epithelial-to-mesenchymal transition by regulating the GSK3β-mediated Wnt/β-catenin pathway.

Cancer Drug Resist · 2025 · PMC12539222 · PMID 41127339

Europe PMC DOI

hedged sentence

0.0620

closest p · 1.2× alpha

0.0620

boldest claim

The sentences

a negative trendP = 0.062so close (0.05 < p ≤ 0.1)

did not reach statistical significanceP = 0.062so close (0.05 < p ≤ 0.1)

Although CDK4 expression showed a negative trend with OS, this association did not reach statistical significance ( P = 0.062 for CDK4; P = 0.0054 for CDK6) [ Figure 1D ].

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