Preclinical Assessment of Atorvastatin for Treatment of Endocardial Fibroelastosis.

JACC Basic Transl Sci · 2025 · PMC12539480 · PMID 40742359

Europe PMC DOI

hedged sentences

0.0950

closest p · 1.9× alpha

0.0950

boldest claim

The sentences

showed a trendP = 0.095so close (0.05 < p ≤ 0.1)

Further, KLF2 overexpressed EdEECs showed a trend toward increased PECAM1 ( P = 0.095) and reduced ACTA2 ( P = 0.097), additionally indicating KLF2-dependent inhibition of fibrogenic activation ( Supplemental Figure S3 ).

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did not reach statistical significanceP = 0.095so close (0.05 < p ≤ 0.1)

Transcriptional analyses with qRT-PCR gene expression of collagen type I showed a trend toward higher expression in untreated/vehicle-treated hearts, but did not reach statistical significance ( P = 0.095).

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