Metabolically Abnormal Obesity and Carotid Plaque Vulnerability: A Vessel Wall MRI Study Linking Obesity Phenotypes to Atherosclerotic Instability.

Arterioscler Thromb Vasc Biol · 2025 · PMC12542998 · PMID 40964717

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0540

boldest claim

The sentences

near-significantP =0.054so close (0.05 < p ≤ 0.1)

MANW: The Hidden-Risk Phenotype The observed trends in MANW—particularly near-significant IPH prevalence elevation ( P =0.054) versus MHNW and significantly increased wall thickness versus MHO—suggest metabolic dysfunction associates with subclinical vascular pathology independent of BMI.

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approaching significanceno p-value reported

Third, the MHO group exhibited plaque stability similar to MHNW, whereas MANW had a greater plaque burden than MHO and higher IPH prevalence (approaching significance) than MHNW, indicating that metabolic status rather than BMI alone corresponds to atherosclerotic biomarker profiles.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.