Colorectal 15-Lipoxygenase-1 as a Host Factor Determining the Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on Colorectal Tumorigenesis in Mice.

Colorectal tumor multiplicity tended to be lower in EPA-FFA diet-fed WT mice than in control diet-fed WT mice, although the difference failed to reach statistical significance ( P = .14) ( Figure 2 C and D ).

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Lovaza diet-fed WT mice had significantly lower colorectal tumor numbers and volumes than did control diet-fed WT mice; EPA-FFA-fed WT mice had a similar trend, but the difference did not reach statistical significance.

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