Similarly, movement speed showed a trend towards improvement for both finger tapping (from 2.68 ± 1.08 units to 3.01 ± 0.78 units; p = 0.082; Fig. 2h ) and hand opening (from 2.55 ± 0.72 units to 2.88 ± 0.84 units; p = 0.454; Fig. 2i ), though these changes did not reach statistical significance after correction for multiple comparisons.
Similarly, a negative correlation between shorter disease duration and higher bradykinesia severity was observed, albeit this did not reach statistical significance (r = -0.327, p = 0.163).
This spatial separation is clinically highly significant, as it implies that through precise electrode placement and programming, it should be possible to selectively modulate the therapeutic zone while actively avoiding the area that produces bradykinetic side effects.