Acute Chemodenervation of the Bladder With Botulinum Toxin After Spinal Cord Injury Resulted in Preserved Bladder Function in Rodents.

Neurourol Urodyn · 2025 · PMC12550348 · PMID 40735928

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did not reach statistical significanceno p-value reported

Both acute and chronic BoNT‐A treatment resulted in trend towards a decrease in void volume (0.33 ± 0.04 mL and 0.54 ± 0.24 mL respectively), but this difference did not reach statistical significance compared to controls (either SCI or SCI + saline treated group). 3.2.3 Compliance SCI is known to reduce bladder compliance and analysis with one‐way ANOVA showed that there was no statistical difference in the effect of treatment ( p > 0.05; Figure 4 ).

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showed a trendno p-value reported

There was a trend towards decreased compliance after SCI compared to Sham animals, and only SCI + acute BoNT‐A treated animals showed a trend towards preserved compliance compared to Sham.

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