Association between cerebrospinal fluid CXCL10 and neurocognitive disorders in people living with HIV: a meta-analysis.

AIDS Res Ther · 2025 · PMC12551246 · PMID 41137028

Europe PMC DOI

hedged sentences

0.1300

closest p · 2.6× alpha

0.1300

boldest claim

The sentences

failed to reach statistical significancep = 0.13not close (p > 0.1)

In addition, pooled analysis of three datasets assessing the odds of HAND in relation to high versus low CSF CXCL10 failed to reach statistical significance (OR: 1.36, p = 0.13), suggesting that while CXCL10 elevation correlates with HAND, its predictive utility as a categorical biomarker remains uncertain and requires further validation.

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did not reach statistical significanceno p-value reported

Among these, ART proportion and blood CD4 + count explained the highest proportion of between-study variance (adjusted R2 = 29.2% and 25.6%, respectively), although these results did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.