Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment.

Neuroimage Clin · 2025 · PMC12552153 · PMID 41092763

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nominally significantno p-value reported

Findings described as ‘nominally significant’ did not survive FDR correction and should be interpreted as exploratory. 3 Results 3.1 Descriptives The sample was characterized by participants in three different diagnostic groups: A− CU (N = 363), MCI due to AD (A+; N = 474), and individuals diagnosed with AD dementia (A+; N = 214).

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did not reach statistical significanceno p-value reported

However, these interactions did not reach statistical significance after FDR correction, and the overall directionality of effects was consistent across sexes.

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