Heterogeneous expression of immunotherapy response markers in non-small cell lung cancer with hyperactive NRF2 pathway: PD-L1 and beyond.

In contrast, CD274 /PD-L1 mRNA showed a trend to reduced expression in KEAP1 -mutated and a significantly decreased level in NRF2 signature-high cells from CCLE ( Fig. 7 B–C, top).

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Mutant KRAS , in turn, displayed a numerically reduced frequency in the two ICI-Immune-high clusters, k5 and k4, even though it did not reach statistical significance (p-adj = 0.152, Chi-squared among clusters) ( Fig. 2 D and E).

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