Integrated study of DNA methylation and transcriptome: a new perspective for exploring the pathogenesis of Sjögren's syndrome.

Epigenetics Chromatin · 2025 · PMC12557958 · PMID 41146282

Europe PMC DOI

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closest p · 1.0× alpha

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boldest claim

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did not reach statistical significanceP > 0.05actually significant

But due to considerable intra-group individual differences and limited sample size, the differences in LCP2 , BTK , ARHGAP9 , WDFY4, CSF2RB , and ARHGAP25 did not reach statistical significance ( P > 0.05).

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an overall trendno p-value reported

The number of hypermethylated DMRs was significantly greater than that of hypomethylated DMRs, which could indicate an overall trend toward increased methylation levels in SS.

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a significant trendno p-value reported

The results demonstrated that compared with normal control tissues, the mRNA levels of the above 9 hub genes all exhibited a significant trend of high expression in the parotid gland tissues of SS, consistent with the trends observed in the GSE40611 dataset.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.