Upregulation of ALDH1 as an adaptive epigenetic response to anthracyclines in acute myeloid leukemia.

Hemasphere · 2025 · PMC12560172 · PMID 41164352

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did not reach statistical significanceP = 0.08so close (0.05 < p ≤ 0.1)

showed a trendno p-value reported

ALDH1A2 expression showed a trend toward reduced OS but did not reach statistical significance in the overall AML cohort (P = 0.08), nor in the chemotherapy‐treated (P = 0.09) or relapsed/refractory subgroups (P = 0.2) (Supporting Information S10: Figure 1 ; Supporting Information S2: Table 2 ).

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a nonsignificant trendno p-value reported

Consistent with the expression patterns described above, ALDH1‐specific enzymatic activity increased significantly in response to DNR in K562, Kasumi‐1, and Mono‐Mac‐6, while only a nonsignificant trend was observed in KG1a (Figure 2E ).

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