Gender- and Grade-Dependent Activation of Androgen Receptor Signaling in Adult-Type Diffuse Gliomas: Epigenetic Insights from a Retrospective Cohort Study.

Biomedicines · 2025 · PMC12561669 · PMID 41153666

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showed a trendno p-value reported

After adjusting the Cox Regression Model for MGMT-methylation status and gender, AR expression only showed a trend in impacting survival, without reaching statistical significance ( p -value 0.12; HR = 2.25 (0.79–6.39)) ( Table 3 ). 3.3.

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did not reach statistical significanceno p-value reported

In this analysis, the MGMT-methylation status confirmed its prognostic role ( p -value 0.04; HR = 0.34 (0.12–0.95)), while AR expression did not reach statistical significance ( p -value 0.27; HR = 1.68 (0.67–4.26)), likely due to the small sample size.

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