Neurotransmitter Levels (Dopamine, Epinephrine, Norepinephrine, Serotonin) and Associations with Lipid Profiles in Patients with Prediabetes or Newly Diagnosed Type 2 Diabetes Mellitus.

Int J Mol Sci · 2025 · PMC12562771 · PMID 41155361

Europe PMC DOI

hedged sentences

0.0380

closest p · 0.8× alpha

0.0780

boldest claim

The sentences

highly significantp = 0.038actually significant

Associated lipid indices (TyG, TyG-BMI, TyG-WC, and TyG-WHtR) showed that TyG had a highly significant p -value (<0.0001), followed by TyG-WC index ( p = 0.038).

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approached significancep = 0.0624so close (0.05 < p ≤ 0.1)

The effect of sex (male) approached significance in the EPI model (EPI: Coefficient β = −127.11, p = 0.0624), with a negative coefficient indicating lower EPI levels in males compared to females.

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near-significantp = 0.072so close (0.05 < p ≤ 0.1)

T2DM: Only EPI showed a near-significant ( p = 0.072) sex difference, with higher levels in females.

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a positive trendp = 0.078so close (0.05 < p ≤ 0.1)

In PreDM, ST shows a positive trend with BMI, approaching statistical significance ( p = 0.078).

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marginal significanceno p-value reported

Exploratory Correlation Analysis in PreDM Group Although no correlations passed the FDR threshold (q-value < 0.05), two pairwise associations in the PreDM group ( Table 9 ) showed marginal significance at the unadjusted p -value level (<0.05).

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