Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesis.

45-68 weeks old CSB mice did not show body weight differences compared to controls in females; however, males showed a trend toward weight loss ( p value 0.07) (Fig. 1A ).

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A similar trend was observed in CSB mice, though it did not reach statistical significance.

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Changes in serum uric acid level were not statistically significant but showed an increasing trend in CS mice (Fig. 3G ).

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In contrast, CSB-deficient mice are small with a highly significant reduction in body weights in males.

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