Deep clinical, genetic, and serum biomarker profiling indicates glial and neuronal pathology in primary brain calcification.

GFAP showed a strong trend towards elevated concentrations in both genetic and no identified mutation PBC compared with controls but did not reach statistical significance ( Table 3 and Fig. 4E ).

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Moreover, there was also a trend towards lower serum calcium in no identified mutation PBC when compared with controls, however it did not reach statistical significance ( Table 3 and Fig. 3G ).

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