borderline non-significantp value = 0.055
Collagen showed a borderline non-significant effect on skin barrier integrity (pSMD [95% CI] = − 0.21 [− 0.42, 0.004], p value = 0.055) with moderate heterogeneity (I 2 = 57.7%) and no indication of publication bias (Egger’s test p value = 0.4799).