Gender differences in the predictive value of serum uric acid for major adverse cardiovascular events in patients with acute coronary syndromes: a retrospective cohort study.

However, after adjustment by multivariate Cox regression analysis via covariates, SUA (1 mg/dL) was a significant predictor of the risk of MACE only in men (HR 1.21,95% CI 1.03, 1.42, p = 0.0191), and in women, although it was shown to increase by 6% in the occurrence of a MACE event with each one-unit increase in UA, the p -value did not reach statistical significance (HR 1.06,95% CI 0.82, 1.38, p = 0.6633).

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After adjusting for variables, smoothed-fit curve analysis similarly showed a trend toward higher MACE occurrence with elevated uric acid in a variety of populations.

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