Improving immunotherapy responses by dual inhibition of macrophage migration inhibitory factor and PD-1.

Additional flow cytometry analyses showed a nonsignificant trend toward increased cDC populations with anti-MIF but significant increases in cDCs expressing Cd74 and Ccr7 separately, compared with anti–PD-1 treatment, highlighting DC heterogeneity ( P < 0.05).

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Due to locus heterogeneity at the -794 CATT 5-8 microsatellite, genetic association studies in small cohort studies may be significant at the -173 G/C but not at the -794 CATT 5-8 site.

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Tumors from anti–PD-1/anti-MIF–treated mice showed a trend toward more CD3 + and CD8 + T cells, fewer CD163 + (M2) macrophages, and higher CD8/CD3 ratios that did not reach statistical significance.

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