Bcl6 expression is associated with a distinct immune landscape and spatial transcriptome in COVID-19.

In contrast, the RF-Bcl6 hi group showed a trend toward a positive association between several genes and B cells, reaching significance for TRAF2 ( Figure 6B ), as well as between Tfh cells and TNFRSF1A/TNF-R1 ( Figure 6B ).

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We observed a clear trend for closer proximity between PD1 hi CD57 hi Tfh cells and CD20 hi/dim Ki67 hi B cells in RF-Bcl6 hi tissues compared with HLN-Controls and RF-Bcl6 int , suggesting increased B/T cell interactions in this group.

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