Evaluation of salivary and serum Exosomal mRNAs as biomarkers for the diagnosis and prognosis of oral squamous cell carcinoma.

Sci Rep · 2025 · PMC12583773 · PMID 41184439

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a clear trendno p-value reported

A clear trend of increasing gene expression was observed from grade I to grade III in saliva samples (Figs. 6 and 7 ), whereas serum-derived exosomal markers did not show any statistically significant association with tumor grades (Supplementary Table 2), highlighting the superior discriminatory potential of saliva.

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did not reach statistical significancep = 0.066so close (0.05 < p ≤ 0.1)

an increasing trendno p-value reported

Although IL6 demonstrated an increasing trend across grades, the difference between grade I and III did not reach statistical significance ( p = 0.066), suggesting a weaker grade-association.

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