Effect of the Combination of Concomitant Drugs on Efficacy of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer.

Cancer Rep (Hoboken) · 2025 · PMC12590243 · PMID 41195639

Europe PMC DOI

hedged sentences

0.0950

closest p · 1.9× alpha

0.0950

boldest claim

The sentences

showed a trendp = 0.095so close (0.05 < p ≤ 0.1)

ECOG PS of 2–4 was significantly associated with worse OS (HR: 2.51, 95% CI: 1.39–4.54, p = 0.002) and showed a trend toward worse PFS (HR: 1.65, 95% CI: 0.92–2.97, p = 0.095).

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a favorable trendno p-value reported

Although these differences were not statistically significant (PFS: p = 0.225, OS: p = 0.939), a favorable trend was observed in the low‐dose aspirin group.

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did not reach statistical significanceno p-value reported

Although the differences in PFS ( p = 0.053) and OS ( p = 0.194) did not reach statistical significance, the PPI + aspirin group exhibited a trend toward improved outcomes (Figure 3A,B ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.