Enhanced bone regeneration in critical-size defects using novel ultralong hydroxyapatite microtubes/chitosan composite scaffolds.

This trend became more pronounced at day 7, where highly significant differences (*** p < 0.001) were observed between all groups, with HMTs–CHS showing the highest proliferation rate, followed by CHS, and the Blank group showing the lowest rate.

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At 60-day post-surgery (Table 1 ), while absolute bone volume (BV) showed a trend toward higher values in the HMTs–CHS group (13.92 ± 1.36 mm 3 ) compared to CHS (11.12 ± 2.71 mm 3 ) and blank groups (10.28 ± 1.41 mm 3 ), this difference did not reach statistical significance ( p = 0.060).

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