Complete loss of SLC30A8 in humans improves glucose metabolism and beta cell function.

We also observed higher insulin levels in LoF heterozygotes and homozygotes in the first 30 min of the test (β=0.59, p =2.6×10 –3 ) and a nominally significant trend toward elevated insulin levels throughout (β=0.34, p =0.03).

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A significantly higher CIR30 (β=0.79, p =1.9×10 –4 ) was noted for LoF genotypes, but changes in the ISI did not reach statistical significance.

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