Comparison of <i>MALAT1</i> antisense oligonucleotide distribution following intracerebroventricular and lumbar intrathecal routes of administration.

In the deep brain regions, where IT delivery has struggled to demonstrate significant RNA KD in other large animal models, 9 , 11 ICV delivery resulted in significantly enhanced KD in the caudate and showed a trend toward more KD in the thalamus that did not reach statistical significance ( Figure 7 B).

also in 53,322 other papers