Breaking epigenetic shackles: targeting ARID1A methylation and the PI3K/AKT/mTOR-PD-L1 axis to overcome immune escape in gastric cancer.

PeerJ · 2025 · PMC12596888 · PMID 41215803

Europe PMC DOI

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closest p · 1.0× alpha

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did not reach statistical significancep > 0.05actually significant

showed a trendp > 0.05actually significant

Although ARID1A promoter methylation levels through UALCAN ( Chandrashekar et al., 2022 ) showed a trend toward reduction in normal gastric mucosa, this difference did not reach statistical significance ( p > 0.05; Fig. 1A ).

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