Molecular features influencing clinical outcome of advanced HER2-positive gastric cancer receiving trastuzumab plus chemotherapy.

Ann Med · 2025 · PMC12599165 · PMID 41195584

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0940

boldest claim

The sentences

borderline significancep = 0.050actually significant

In contrast, most acquired genomic features were not significantly correlated with PFS, except for the number of acquired alterations, which demonstrated borderline significance ( p = 0.050).

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showed a trendp = 0.094so close (0.05 < p ≤ 0.1)

6.0 months, p = 0.036) compared to those with TOP2A WT, and showed a trend towards improved OS (mPFS: not reached (NR) vs. 20.3 months, p = 0.094) ( Figure 2(C,D) and Table S1 ).

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a statistical trendno p-value reported

Despite conflicting results across studies, multivariate analysis in our cohort indicated that TMB was not an independent factor associated with PFS, although a statistical trend existed.

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did not reach statistical significanceno p-value reported

TMB-H was associated with shorter PFS, whereas higher CIS suggested a trend for better PFS, though it did not reach statistical significance.

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