Intestinal mucosal alterations parallel central demyelination and remyelination: insights into the gut-brain axis in the cuprizone model of multiple sclerosis.

Both iNOS and HO-1 exhibited increased expression levels at the demyelination peak, which then declined toward baseline during remyelination, although these changes did not reach statistical significance.

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In parallel, animals showed a trend toward elevated NF-κB expression and decreased levels of its repressor Nkrf.

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