Lovastatin-Loaded Nanoparticles in a Thermosensitive Chitosan Hydrogel as a Sustained Release System for Treating Intervertebral Disc Degeneration: In Vitro Cell Culture Study and In Vivo Evaluation Using a Needle-Puncture Induced Degeneration Model in Rat Caudal Discs.

JOR Spine · 2025 · PMC12602262 · PMID 41230223

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did not reach statistical significancep ‐value = 0.081so close (0.05 < p ≤ 0.1)

showed a trendno p-value reported

mRNA Expressions of Human Nucleus Pulposus Cells Treated With C/G/GP Hydrogel Containing LVS‐NPs After 24 h of treatment, the human nucleus pulposus cells treated with 5 μM lovastatin (group L) showed a trend toward higher mRNA expression of ACAN , DCN , and SOX9 compared with the other groups, although the difference did not reach statistical significance ( p ‐value = 0.081, 0.070, and 0.092, respectively; Figure 5A ).

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