Extracellular Vesicles From Multiple Sclerosis White Matter Exhibit Synaptic, Mitochondrial, Complement and Ageing-Related Pathway Dysregulation.

While MS EVs exhibited signs of accelerated brain ageing compared to control EVs, the difference did not reach statistical significance, given our sample size.

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While there was also no significant difference in median particle size, MS EVs showed a trend towards larger particles and a slightly different size distribution pattern (Figure 1B , Figure S1E ).

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