HIF-1 Targeting Intervention Renders Protection From Alzheimer's-Like Pathology in a Humanized Mice Model of HIV Infection.

Additionally, restoration of AβmOC64, GAD65 and Drebrin, though not significant, showed a trend of improvement in the HIV + +HIF‐1 siRNA group as compared to the HIV+ group.

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At 2 months post‐infection, although these differences did not reach statistical significance, we observed consistent directional trends indicative of continued impairment in novelty recognition and reduced exploratory drive, possibly reflecting a transition from acute to chronic neurocognitive effects.

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In contrast, they exhibited an increasing trend in anticlockwise rotations, suggesting a behavioural asymmetry that may be linked to compensatory movement patterns or potential hemispheric imbalances in basal ganglia or cortical control circuits, often associated with neurodegenerative conditions (Sullivan et al. 1994 ).

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