Profiling fear-extinction learning induced small ncRNAs landscape and identifying miR-29b-3p as a promising biomarker for PTSD.

Although miR-144-3p [ 5 ], which our group has shown to play a crucial role in rescuing impaired fear extinction, did not meet the stringent false discovery rate (FDR) threshold, it was nominally significant with a p-value < 0.05 and thus qualifies as a DE miRNA under less stringent criteria.

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In our study, Dnmt3a expression in the mPFC exhibited a decreasing trend following EXT training, although the change did not reach statistical significance (Fig. 5 B).

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