Effectiveness and Safety of Talc Slurry Pleurodesis in the Treatment of Patients with Malignant Pleural Effusion and Low Karnofsky Performance Status Scores.

J Clin Med · 2025 · PMC12610753 · PMID 41226924

Europe PMC DOI

hedged sentences

0.1030

closest p · 2.1× alpha

0.1500

boldest claim

The sentences

showed a trendp = 0.103not close (p > 0.1)

Elevated lactate dehydrogenase (LDH) levels showed a trend toward poorer survival (unadjusted HR = 0.34; 95% CI: 0.09–1.24; p = 0.103), which became attenuated and non-significant in the adjusted model (adjusted HR = 0.47; 95% CI: 0.13–1.74; p = 0.256).

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did not reach statistical significancep = 0.150not close (p > 0.1)

Remarkably, the neutrophil-to-lymphocyte ratio (NLR) in pleural effusion was elevated in the failure group (median 0.26, IQR 0.19–0.53) when compared with the success group (median 0.16, IQR 0.05–0.46), although the difference did not reach statistical significance ( p = 0.150).

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